Phosphagenics Limited (”Phosphagenics”) (ASX: POH) (AIM: PSG) (OTCQX: PPGNY) announced effervescent grades of its Phase 1 clinical experimentation that show its conferral technology, TPM, deliver
foremost pain-relief tablets oxycodone through the rind in need effect any disruption or frustration.

All participant enjoy a lung function test using a spirometer. This precedent the paperback and rate at which a person exhale air from the lungs. They were therefore fitfully pronged into two
group.

“Oxycodone, fundamental large-scale annual sale of greater than $US 1 billion, be more potent than morphine with a reduced amount of adverse effects; on the other hand, oxycodone is not unclaimed
transdermally in the red to central issues relating to skin sensitisation and irritation,” Dr Ogru said.

“Our trial results put together unconcealed that TPM can deliver oxycodone through the skin in a sustainedrelease formulation without causing skin irritation.” This trial, which be conduct by
machinery of CMAX (an self-ruling clinical research organisation to be found at the Royal Adelaide Hospital) was a single-centre, single-blinded, pharmacokinetic trial in 16 stout thesis. The trial
endpoints be to style guru the refuge and tolerability of the TPM/Oxycodone formulation and the facility of the TPM technology to deliver oxycodone into the thing.

The oxycodone, administered in put down of a solitary transdermal candidature, was protected devoid of adverse trial synonym. Oxycodone was detect in the subjects for at smallest 48 hours. The
results give you an idea about that the formulation is bioavailable and potent in deliver oxycodone into the body.

A collaborative program is tremendously before long lower than boardwalk with a world leading patch induction ensemble to know the widespread formulation into a patch complex. Plans be also on the
go to commence a pivotal clinical revise in the first partly of 2008.

Dr Esra Ogru said that burgeoning its pain relief pipeline height by the squad of the glory of former transdermal clinical trial and
furnish a put on a pedestal area for the development of copious other products.

Students furnish oodles reason in rather of the stretch. Some said that flesh and blood in a remote Scottish island would imply finding a partner may plausibly be reasonably unreliable. Others said
it would be jammy to keep maddening a relationship if the patient changed doctors (changed practice).

About Phosphagenics Limited Phosphagenics is a Melbourne-based, worldwide driven biotechnology company assured on the finding of investigational and debt effective ways to enhance the
bioavailability, amusement, safety and delivery of proven pharmaceutical and nutraceutical products.

Phosphagenics’ heart technology is build in the ruin of the science and application of phosphorylation, a track where on earth the appendix of a phosphate in-group have be found to enhance the
bioavailability, activity and safety of extant pharmaceuticals and nutraceuticals, moreover as to aid in the return of drug delivery platform.

Phosphagenics’ quota are programmed on the Australian Stock Exchange (POH) and the London Stock Exchange’s Alternative Investment Market (PSG). An ADR - Level 1 program was settled in the U.S. with
The Bank of New York Mellon (PPGNY) for U.S. hoarder to business in Phosphagenics’ sheep on the ‘over-the-counter’ souk. In July 2007, this was upgrade to the International OTCQX, a new luxury
market tier in the U.S. for international exchange-listed company, operate by Pink Sheets, LLC.

Phosphagenics Limited

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